Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses
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Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses.
Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenousl...
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Guaifenesin is an expectorant commonly used in performance horses to aid in the clearance of mucus from the airways. Guaifenesin is also a centrally acting skeletal muscle relaxant and as such is a prohibited drug with withdrawal necessary prior to competition. To the authors' knowledge, there are no reports in the literature describing single or multiple oral administrations of guaifenesin in ...
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Lena Olsén 2007. Drugs in horses: pharmacokinetics and pharmacodynamics Doctoral thesis ISSN 1652-6880, ISBN978-91-576-7336-7 In this thesis the fate and effect of some drugs have been examined in horses. Studies have also been performed to explore some factors which may affect the pharmacokinetics and the pharmacodynamics of drugs in horses. Investigations on the drug metabolising enzyme cytoc...
متن کاملElimination of cetirizine following administration of multiple doses to exercised thoroughbred horses.
Cetirizine is an antihistamine used in performance horses for the treatment of hypersensitivity reactions and as such a withdrawal time is necessary prior to competition. The objective of the current study was to describe the disposition and elimination of cetirizine following oral administration in order to provide additional serum concentration data upon which appropriate regulatory recommend...
متن کاملFrequency of Limb Injuries Between Thoroughbred and Arabian Horses
This study aimed to investigate the relationship between race horse breed and the frequency of limb injuries through the time of training and racing. The study population consisted of 4042 Thoroughbred and 2553 Arabian horses raced at Warsaw race Track, from 2000 to 2008. Among these horses, 94 Thoroughbreds and 32 Arabians had different limb injuries. Based on the achieved results, it is possi...
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ژورنال
عنوان ژورنال: Drug Testing and Analysis
سال: 2017
ISSN: 1942-7603
DOI: 10.1002/dta.2214